Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mechanismszodiac signs march 15

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Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mecha

Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mechanismszodiac signs march 15

Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mechanismszodiac signs march 15

Summary: While patients with schizophrenia, major depressive disorder, and bipolar disorder experience a lack of motivation and anhedonia, the neural patterns of emotion-behavior dissociation differ between the disorders.

Source: Chinese Academy of Sciences

Anhedonia and amotivation are common symptoms in patients with schizophrenia, major depressive disorder and bipolar disorder, suggesting the need to explore the underlying behavioral and neural mechanisms in order to facilitate the development of effective therapeutic programs and social function rehabilitation.

Accumulating evidence indicates that the nature of anhedonia may not be only due to deficits in pleasure experience or reward pursuit motivation, but may also be related to failure in translating emotional salience into effortful behavior.

Most of the previous studies were mainly limited to behavioral measures and examination of patients with only one diagnostic group without comparison to other mental disorders.

Dr. Raymond Chan and his team from the Institute of Psychology of the Chinese Academy of Sciences have recently showed that although patients with schizophrenia, major depressive disorder and bipolar disorder all exhibit a lowered capacity to experience pleasure as well as a lack of motivation, the pattern of emotion-behavior dissociation is different across patients.

The researchers have conducted a study to examine the neural correlates of effort-expenditure for reward across these patients.

They recruited 20 patients with schizophrenia, 23 with major depression, 17 with bipolar disorder, and 30 healthy controls to complete an Effort-Expenditure for Reward Task (EEfRT) in a 3T brain scanner. The task used an event-related design and consists of six conditions, crossed by reward magnitude (low, high) and reward probability (20 percent, 50 percent, 80 percent). The proportion of high-effort tasks selected at different probabilities reflected participants’ motivation to pursue rewards.

According to the researchers, the three groups exhibited shared activations in the cingulate gyrus, the medial frontal gyrus and the middle frontal gyrus during the EEfRT administration. Patients with schizophrenia showed stronger variations of functional connectivity between the right caudate and the left amygdala, the left hippocampus and the left putamen, with increase in reward magnitude comparing to healthy controls.

According to the researchers, the three groups exhibited shared activations in the cingulate gyrus, the medial frontal gyrus and the middle frontal gyrus during the EEfRT administration. Image is in the public domain

Additionally, patients with major depressive disorder exhibited an enhanced activation compared to healthy controls in the right superior temporal gyrus when there was an increase of reward magnitude. The variations of functional connectivity between the caudate and the right cingulate gyrus, the left postcentral gyrus and the left inferior parietal lobule with increase in reward magnitude were weaker than that found in healthy controls.

In addition, patients with bipolar disorder exhibited an increased activation in the left precuneus but a decreased activation in the left dorsolateral prefrontal cortex when there was an increase in reward probability compared to healthy controls.

Taken together, these findings demonstrate patients with schizophrenia, major depressive disorder and bipolar disorder exhibit both shared and distinct neural mechanisms associating with effort-based decision-making. This may have important implications for the development of neuro-modulation intervention to alleviate anhedonia and amotivation in these disorders.

zodiac signs march 15Patients With Schizophrenia, Major Depression and Bipolar Disorder Have Distinct Reward Neural Mechanisms

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